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compound 991  (Selleck Chemicals)


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    Selleck Chemicals compound 991
    Compound 991, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound+991/ex229/pm41423271-339-0-2
    Average 93 stars, based on 15 article reviews
    compound 991 - by Bioz Stars, 2026-10
    93/100 stars

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    other:

    Article Title: CRISPR screens decode cancer cell pathways that trigger γδ T cell detection
    Article Snippet: 20 μL of zoledronate, rotenone (MedChemExpress), oligomycin A (Neta Scientific), FCCP (MedChemExpress), antimycin A (Neta Scientific), AICAR (Sigma), 2-deoxy-D-glucose (2-DG) (Sigma), Compound 991 (Selleck Chemical), A-769662 (Sigma), metformin hydrochloride (MedChemExpress), ethanol (vehicle), or DMSO (vehicle, at dilutions matching the treatment) at various concentrations were added to the cells.

    Article Title: Frataxin depletion leads to decreased soma size and activation of AMPK metabolic pathway in dorsal root ganglia sensory neurons
    Article Snippet: Neuronal cultures were treated starting at 7 div (unless indicated) with either (±)-α-Lipoic acid (ALA; Merck T1395), AICAR (Merck, A9978), N-Acetyl-L-cysteine (Merck A7250), Compound 991 (Selleckchem ex229; S8654) or Rapamycin (Merck R8781).

    Article Title: AMPK activator 991 specifically activates SnRK1 and thereby affects seed germination in rice.
    Article Snippet: Sucrose non-fermenting-1-related protein kinase 1 (SnRK1) and AMP-activated protein kinase (AMPK) are highly conserved.. Compound 991 is an AMPK activator in mammals.. However, whether 991 also activates SnRK1 remains unknown.

    Concentration Assay:

    Article Title: AMPK agonism optimizes the in vivo persistence and anti-leukemia efficacy of chimeric antigen receptor T cells
    Article Snippet: .. Compound 991 (SelleckChem S8654, Table S1) was reconstituted in DMSO and added to cultures at a final concentration of either 10 or 25μM on Days 5 and 7. ..

    Article Title: AMPK agonism optimizes the in vivo activation and antileukemic efficacy of chimeric antigen receptor T cells
    Article Snippet: .. Compound 991 (SelleckChem S8654, ) was reconstituted in DMSO and added to cultures at a final concentration of either 10 or 25 μM on days 5 and 7. ..

    Article Title: AMPK agonism optimizes the in vivo activation and antileukemic efficacy of chimeric antigen receptor T cells.
    Article Snippet: .. Compound 991 (SelleckChem S8654, online supplemental table S1) was reconstituted in DMSO and added to cultures at a final concentration of either 10 or 25 μM on days 5 and 7. ..

    In Vitro:

    Article Title: Activity-dependent subcellular compartmentalization of dendritic mitochondria structure in CA1 pyramidal neurons
    Article Snippet: .. Cells were brought to 21 days in vitro (DIV) and then treated with either DMSO (2.5μM, Santa Cruz Biotechnology), STO609 (2.5μM, Sigma-Aldrich), or Compound 991 (50μM, Selleck Chem) for 2.5 hours. .. Neurobasal media was then switched out for 5K Tyrode Solution containing TTX (1μM, Hello Bio) to block sodium channels, NMDA antagonist AP5 (10μM, Hello Bio), and AMPA antagonist NBQX (50μM, Hello Bio) for 30 minutes to dampen cell activity.



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    Compound C (5 μM; an <t>AMPK</t> <t>inhibitor),</t> compound 991 (250 nM; an AMPK activator), PF-739 (250 nM; an AMPK activator) or DMSO control were added into the kinase reaction (40 min reaction time) in the presence or absence of AMP. OD values from the ELISA following the kinase reactions were measured and compared, n = 4. For each treatment condition, the OD value from 0 min reaction was determined and considered as blank, and was subtracted from the OD value of the experimental condition. **** p < 0.0001 when comparing to control condition with the same AMP availability in the reaction using Student’s t-test. $ p < 0.05, $$$ p < 0.001, $$$$ p < 0.0001 when comparing to the condition with the same modulator treatment but with the presence of AMP using Student’s t-test. Data are mean ± s.e.m.
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    Compound C (5 μM; an AMPK inhibitor), compound 991 (250 nM; an AMPK activator), PF-739 (250 nM; an AMPK activator) or DMSO control were added into the kinase reaction (40 min reaction time) in the presence or absence of AMP. OD values from the ELISA following the kinase reactions were measured and compared, n = 4. For each treatment condition, the OD value from 0 min reaction was determined and considered as blank, and was subtracted from the OD value of the experimental condition. **** p < 0.0001 when comparing to control condition with the same AMP availability in the reaction using Student’s t-test. $ p < 0.05, $$$ p < 0.001, $$$$ p < 0.0001 when comparing to the condition with the same modulator treatment but with the presence of AMP using Student’s t-test. Data are mean ± s.e.m.

    Journal: bioRxiv

    Article Title: An Enzyme-Linked Immunosorbent Assay (ELISA)-based Activity Assay for AMP-Activated Protein Kinase (AMPK)

    doi: 10.1101/2024.08.20.608877

    Figure Lengend Snippet: Compound C (5 μM; an AMPK inhibitor), compound 991 (250 nM; an AMPK activator), PF-739 (250 nM; an AMPK activator) or DMSO control were added into the kinase reaction (40 min reaction time) in the presence or absence of AMP. OD values from the ELISA following the kinase reactions were measured and compared, n = 4. For each treatment condition, the OD value from 0 min reaction was determined and considered as blank, and was subtracted from the OD value of the experimental condition. **** p < 0.0001 when comparing to control condition with the same AMP availability in the reaction using Student’s t-test. $ p < 0.05, $$$ p < 0.001, $$$$ p < 0.0001 when comparing to the condition with the same modulator treatment but with the presence of AMP using Student’s t-test. Data are mean ± s.e.m.

    Article Snippet: AMPK inhibitor, compound C (cat# AOB2281), and AMPK activators, compound 991 (cat# AOB8150) and PF-739 (cat# AOB33584), were purchased from AOBIOUS (Gloucester, MA, USA).

    Techniques: Control, Enzyme-linked Immunosorbent Assay